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Biopharma & FDA Affairs

Structuring Milestone Payouts in Phase 3 Oncology Drug Licensing Deals

Biotech founders often agree to back-weighted milestone schedules that leave them cash-starved during costly Phase 3 clinical trials. Here is how to negotiate upfront developmental tranches.

Amit Kasliwal
Amit KasliwalCEO & Founder, Dehurdle
March 26, 20234 min read
Structuring Milestone Payouts in Phase 3 Oncology Drug Licensing Deals

The Developmental Milestone Tranche Script

Recommended Spoken Script
"To ensure our Phase 3 trial enrollment meets the 18-month FDA timeline, we require a $45M upfront licensing payment and $30M upon First Patient Dosed. Back-weighting milestones solely to NDA approval forces unnecessary dilution and risks study pacing."

The 2-Minute Practice Drill

2-Minute Spoken Drill

The 2-Minute Practice Drill

Practice biopharma licensing negotiations in Dehurdle.

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